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by Glen Depke, Traditional Naturopath You may know of someone that suffers from one of more of these challenges.
- Do you find regular joint pain a part of your daily life?
- Are regular body aches beginning to annoy you regularly?
- Is your body stiff when you wake in the morning or after sitting for some time?
- Mental/emotional stress
- Gluten and other cross reactive food intolerance
- Infection
- Obesity
- Chemotherapy
- Addiction
- Understand that chronic inflammation will often inhibit phase I and phase II liver detoxification pathways. This occurs due to the fact that the NF-kB state can create a suppression of cytochrome P450. This suppression leads to a compound hepatic biotransformation, thus activating hepatic end products. It helps to understand that biotransformation is the process of rendering fat-soluble compounds to water soluble compounds so they can be excreted via the urine, feces and sweat. Hormones, toxins and drugs undergo hepatic transformation by phase I and phase II pathways in the liver and are eventually eliminated by a phase III pathway. A significant key though to this biotransformation, phase I, phase II and phase III pathways is the initial release of cytochrome P450. As noted above, chronic inflammation suppresses this cytochrome P450 thus inhibiting the entire liver clearance pathways. When this occurs, further inflammation is initiated and round and round you go. Simply put, the chronic inflammatory state leads to a multiple challenges within the liver, thus leading to more inflammation.
- Chronic inflammation can also cause and increase in fat cell production. This increase in fat cells leads to insulin surges which in turn leads to insulin resistance. And guess what this leads to? If you said more inflammation you are right on.
- Another challenge created by chronic inflammation is the creation of leaky gut. Leaky gut occurs when the tight junctures, or openings, in your small intestines that allow your macro-nutrients, vitamins, minerals, enzymes and and co-enzymes, actually become enlarged. When this occurs, whole food substances will be allowed through these tight junctures and lead initially to an autoimmune reaction. As this autoimmune reaction continues this can lead to a true TH-17 response AKA, tissue destruction and your guessed it, more inflammation.
- Last but not least, when you are living with chronic inflammation, your body may respond by raising cytokine production. Cytokines are proteins secreted by immune cells that act on other cells to coordinate appropriate immune responses. When these cytokines are responding to chronic inflammation, this often leads to autoimmune disease and more inflammation.
